IMPACTOS DPS CORANTES ARTIFICIAIS NA SAÚDE INFANTIL: ASSOCIAÇÃO COM SINTOMAS DO TDAH
DOI:
https://doi.org/10.36557/2674-9432.2026v5n4p1027-1045Palavras-chave:
TDAH; alimentação infantil; comportamento infantil; nutrição.Resumo
O presente estudo analisou a associação entre o consumo de corantes artificiais e o agravamento de sintomas relacionados ao Transtorno de Déficit de Atenção e Hiperatividade (TDAH) em crianças. Trata-se de uma revisão integrativa da literatura, de abordagem qualitativa, realizada nas bases PubMed, SciELO, Biblioteca Virtual em Saúde (BVS) e Google Acadêmico, incluindo estudos publicados entre 2015 e 2025. Os resultados demonstraram que os corantes artificiais presentes em alimentos ultraprocessados podem atuar como fatores agravantes de alterações neurocomportamentais, como hiperatividade, impulsividade e dificuldade de concentração, especialmente em crianças predispostas ao TDAH. Além disso, observou-se que estratégias alimentares mais saudáveis e a redução do consumo de ultraprocessados podem contribuir para melhora da qualidade de vida e do desempenho cognitivo infantil. Conclui-se que a temática possui relevância para a Nutrição e para a Saúde Pública, destacando a importância de ações preventivas e educativas voltadas à alimentação infantil saudável.
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Referências
AMCHOVÁ, P.; SISKA, F.; RUDA-KUCEROVÁ, J. Food safety and health concerns of synthetic food colors: an update. Toxics, Basel, v. 12, n. 7, p. 466, 2024. DOI: https://doi.org/10.3390/toxics12070466.
BARKLEY, R. A. Attention-deficit hyperactivity disorder: a handbook for diagnosis and treatment. 4. ed. New York: Guilford Press, 2018.
DAMOTHARAN, K. et al. Biochemical processes mediating neurotoxicity induced by synthetic food dyes. Chemosphere, Oxford, v. 357, p. 142291, 2024. DOI: https://doi.org/10.1016/j.chemosphere.2024.142291.
KAMAL, M.; BENER, A.; EHLAYEL, M. S. Is high prevalence
of vitamin D deficiency a correlate for attention deficit hyperactivity disorder? ADHD Attention Deficit and Hyperactivity Disorders, Vienna, v. 6, n. 2, p. 73-78, 2014. DOI: https://doi.org/10.1007/s12402-
013-0110-5.
KWON, Y. et al. Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice. Nature Communications, London, v. 13, n. 1, p. 7617, 2022. DOI: https://doi.org/10.1038/s41467-022-35309-y.
LAU, K. et al. Synergistic interactions between commonly used food additives in a developmental neurotoxicity test. Toxicological Sciences, Oxford, v. 90, n. 1, p. 178-187, 2006. DOI: https://doi.org/10.1093/toxsci/kfj097.
MCCANN, D. et al. Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled trial. The Lancet, London, v. 370,
n. 9598, p. 1560-1567, 2007. DOI: https://doi.org/10.1016/S0140-6736(07)61306-3.
MILLER, M. D. et al. Potential impacts of synthetic food dyes on activity and attention in children: a review of the human and animal evidence. Environmental Health, London, v. 21, n. 1, p. 45, 2022. DOI: https://doi.org/10.1186/s12940-022-00857-0.
NIGG, J. T. et al. Meta-analysis of attention-deficit/hyperactivity disorder, restriction diet, and synthetic food color additives. Journal of the American Academy of Child and Adolescent Psychiatry, New York,
v. 51, n. 1, p. 86-97, 2012. DOI: https://doi.org/10.1016/j.jaac.2011.10.015.
PELSSER, L. M. et al. Diet and ADHD, reviewing the evidence: a systematic review of meta-analyses.
PLOS ONE, San Francisco, v. 12, n. 1, e0169277, 2017. DOI:
https://doi.org/10.1371/journal.pone.0169277.
POSNER, J.; POLANCZYK, G. V.; SONUGA-BARKE, E. Attention-deficit hyperactivity disorder.
The Lancet, London, v. 395, n. 10222, p. 450-462, 2020. DOI: https://doi.org/10.1016/S0140-
6736(19)33004-1.
RAMBLER, R. M. et al. A review of the association between blue food coloring and attention deficit hyperactivity disorder symptoms in children. Cureus, Palo Alto, v. 14, n. 9, e29241, 2022. DOI: https://doi.org/10.7759/cureus.29241.
SAN MAURO MARTÍN, I. et al. Nutritional and environmental factors in attention-deficit hyperactivity disorder (ADHD): a cross-sectional study. Nutritional Neuroscience, London, v. 21, n. 9,
p. 641-647, 2018. DOI: https://doi.org/10.1080/1028415X.2017.1331958.
SANTOS, L. et al. Azo dyes in the food industry: health risks and regulatory perspectives. Critical Reviews in Food Science and Nutrition, Boca Raton, v. 60, n. 15, p. 2523-2538, 2020. DOI: https://doi.org/10.1080/10408398.2019.1643384.
SOARES, A. et al. Food additives in childhood: a review on consumption and health consequences. Revista Paulista de Pediatria, São Paulo, v. 40, e2020321, 2022. DOI: https://doi.org/10.1590/1984-0462/2022/40/2020321.
STEVENSON, J. et al. The role of histamine degradation gene polymorphisms in moderating the effects of food additives on ADHD symptoms. American Journal of Psychiatry, Washington, v. 167, n. 9, p. 1108-1115, 2010. DOI: https://doi.org/10.1176/appi.ajp.2010.09070984.
STEVENS, L. J. et al. Dietary sensitivities and ADHD symptoms: thirty-five years of research. Clinical Pediatrics, Thousand Oaks, v. 50, n. 4, p. 279-293, 2011. DOI: https://doi.org/10.1177/0009922810384728.
TANAKA, T. et al. Reproductive and neurobehavioral effects of brilliant blue FCF in mice. Birth Defects Research Part B: Developmental and Reproductive Toxicology, Hoboken, v. 95, n. 5, p. 395-409, 2012. DOI: https://doi.org/10.1002/bdrb.21034.
THAPAR, A. et al. What have we learnt about the causes of ADHD? Journal of Child Psychology and Psychiatry, Oxford, v. 54, n. 1, p. 3-16, 2013. DOI: https://doi.org/10.1111/j.1469-7610.2012.02611.x.
TRASANDE, L. et al. Food additives and child health. Pediatrics, Springfield, v. 142, n. 2, e20181408, 2018. DOI: https://doi.org/10.1542/peds.2018-1408.
WARD, N. I. et al. The influence of the chemical additive tartrazine on the zinc status of hyperactive children. Journal of Nutritional Medicine, London, v. 1, n. 1, p. 51-57, 1990. DOI: https://doi.org/10.3109/13590849009003152.
WOO, H. D. et al. Dietary patterns in children with attention deficit/hyperactivity disorder (ADHD).
Nutrients, Basel, v. 6, n. 4, p. 1539-1553, 2014. DOI: https://doi.org/10.3390/nu6041539.
ZHANG, Q. et al. The synthetic food dye, Red 40, causes DNA damage, causes colonic inflammation, and impacts the microbiome in mice. Toxicology Reports, Amsterdam, v. 11, p. 221-232, 2023. DOI: https://doi.org/10.1016/j.toxrep.2023.02.007.
AMCHOVÁ, P.; SISKA, F.; RUDA-KUCEROVÁ, J. Food safety and health concerns of synthetic food colors: an update. Toxics, Basel, v. 12, n. 7, p. 466, 2024. DOI: https://doi.org/10.3390/toxics12070466.
BARKLEY, R. A. Attention-deficit hyperactivity disorder: a handbook for diagnosis and treatment. 4. ed. New York: Guilford Press, 2018.
DAMOTHARAN, K. et al. Biochemical processes mediating neurotoxicity induced by synthetic food dyes. Chemosphere, Oxford, v. 357, p. 142291, 2024. DOI: https://doi.org/10.1016/j.chemosphere.2024.142291.
KAMAL, M.; BENER, A.; EHLAYEL, M. S. Is high prevalence
of vitamin D deficiency a correlate for attention deficit hyperactivity disorder? ADHD Attention Deficit and Hyperactivity Disorders, Vienna, v. 6, n. 2, p. 73-78, 2014. DOI: https://doi.org/10.1007/s12402-
013-0110-5.
KWON, Y. et al. Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice. Nature Communications, London, v. 13, n. 1, p. 7617, 2022. DOI: https://doi.org/10.1038/s41467-022-35309-y.
LAU, K. et al. Synergistic interactions between commonly used food additives in a developmental neurotoxicity test. Toxicological Sciences, Oxford, v. 90, n. 1, p. 178-187, 2006. DOI: https://doi.org/10.1093/toxsci/kfj097.
MCCANN, D. et al. Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled trial. The Lancet, London, v. 370,
n. 9598, p. 1560-1567, 2007. DOI: https://doi.org/10.1016/S0140-6736(07)61306-3.
MILLER, M. D. et al. Potential impacts of synthetic food dyes on activity and attention in children: a review of the human and animal evidence. Environmental Health, London, v. 21, n. 1, p. 45, 2022. DOI: https://doi.org/10.1186/s12940-022-00857-0.
NIGG, J. T. et al. Meta-analysis of attention-deficit/hyperactivity disorder, restriction diet, and synthetic food color additives. Journal of the American Academy of Child and Adolescent Psychiatry, New York,
v. 51, n. 1, p. 86-97, 2012. DOI: https://doi.org/10.1016/j.jaac.2011.10.015.
PELSSER, L. M. et al. Diet and ADHD, reviewing the evidence: a systematic review of meta-analyses.
PLOS ONE, San Francisco, v. 12, n. 1, e0169277, 2017. DOI:
https://doi.org/10.1371/journal.pone.0169277.
POSNER, J.; POLANCZYK, G. V.; SONUGA-BARKE, E. Attention-deficit hyperactivity disorder.
The Lancet, London, v. 395, n. 10222, p. 450-462, 2020. DOI: https://doi.org/10.1016/S0140-
6736(19)33004-1.
RAMBLER, R. M. et al. A review of the association between blue food coloring and attention deficit hyperactivity disorder symptoms in children. Cureus, Palo Alto, v. 14, n. 9, e29241, 2022. DOI: https://doi.org/10.7759/cureus.29241.
SAN MAURO MARTÍN, I. et al. Nutritional and environmental factors in attention-deficit hyperactivity disorder (ADHD): a cross-sectional study. Nutritional Neuroscience, London, v. 21, n. 9,
p. 641-647, 2018. DOI: https://doi.org/10.1080/1028415X.2017.1331958.
SANTOS, L. et al. Azo dyes in the food industry: health risks and regulatory perspectives. Critical Reviews in Food Science and Nutrition, Boca Raton, v. 60, n. 15, p. 2523-2538, 2020. DOI: https://doi.org/10.1080/10408398.2019.1643384.
SOARES, A. et al. Food additives in childhood: a review on consumption and health consequences. Revista Paulista de Pediatria, São Paulo, v. 40, e2020321, 2022. DOI: https://doi.org/10.1590/1984-0462/2022/40/2020321.
STEVENSON, J. et al. The role of histamine degradation gene polymorphisms in moderating the effects of food additives on ADHD symptoms. American Journal of Psychiatry, Washington, v. 167, n. 9, p. 1108-1115, 2010. DOI: https://doi.org/10.1176/appi.ajp.2010.09070984.
STEVENS, L. J. et al. Dietary sensitivities and ADHD symptoms: thirty-five years of research. Clinical Pediatrics, Thousand Oaks, v. 50, n. 4, p. 279-293, 2011. DOI: https://doi.org/10.1177/0009922810384728.
TANAKA, T. et al. Reproductive and neurobehavioral effects of brilliant blue FCF in mice. Birth Defects Research Part B: Developmental and Reproductive Toxicology, Hoboken, v. 95, n. 5, p. 395-409, 2012. DOI: https://doi.org/10.1002/bdrb.21034.
THAPAR, A. et al. What have we learnt about the causes of ADHD? Journal of Child Psychology and Psychiatry, Oxford, v. 54, n. 1, p. 3-16, 2013. DOI: https://doi.org/10.1111/j.1469-7610.2012.02611.x.
TRASANDE, L. et al. Food additives and child health. Pediatrics, Springfield, v. 142, n. 2, e20181408, 2018. DOI: https://doi.org/10.1542/peds.2018-1408.
WARD, N. I. et al. The influence of the chemical additive tartrazine on the zinc status of hyperactive children. Journal of Nutritional Medicine, London, v. 1, n. 1, p. 51-57, 1990. DOI: https://doi.org/10.3109/13590849009003152.
WOO, H. D. et al. Dietary patterns in children with attention deficit/hyperactivity disorder (ADHD).
Nutrients, Basel, v. 6, n. 4, p. 1539-1553, 2014. DOI: https://doi.org/10.3390/nu6041539.
ZHANG, Q. et al. The synthetic food dye, Red 40, causes DNA damage, causes colonic inflammation, and impacts the microbiome in mice. Toxicology Reports, Amsterdam, v. 11, p. 221-232, 2023. DOI: https://doi.org/10.1016/j.toxrep.2023.02.007.
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