TRANSTORNO DO SONO REM E SUA LIGAÇÃO COM DOENÇAS NEUROLÓGICAS
DOI:
https://doi.org/10.36557/2674-9432.2026v5n3p1285-1315Keywords:
Transtorno do Sono REM; Neurodegeneração; Doença de Parkinson; Biomarcadores; Sono REM.Abstract
REM Sleep Behavior Disorder (RBD) is characterized by the loss of physiological muscle atonia during REM sleep, allowing individuals to perform movements and vocalizations related to dream content. In recent years, this disorder has gained increasing scientific attention due to its strong association with neurodegenerative diseases, especially Parkinson’s Disease and Dementia with Lewy Bodies. This study aimed to conduct a literature review on RBD and its relationship with neurological diseases, emphasizing neurodegenerative conditions, exploring the underlying pathophysiological mechanisms, neurological and cognitive impacts, as well as possibilities for early diagnosis. This research consisted of a literature review carried out through bibliographic searches in the PubMed, Scopus, Web of Science, and SciELO databases, using articles published between 2019 and 2025 in Portuguese and English. The results demonstrated that RBD has a significant relationship with neurodegenerative processes associated with the accumulation of neurotoxic proteins, such as alpha-synuclein, beta-amyloid, and tau protein, in addition to neuroanatomical changes in the brainstem and dysfunctions of the glymphatic system. Persistent REM sleep alterations were also associated with negative impacts on memory, cognition, and quality of life. It was concluded that RBD represents an important early biomarker of neurodegenerative diseases, highlighting the relevance of early diagnosis and continuous neurological monitoring to prevent complications and monitor neurodegenerative progression.
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Copyright (c) 2026 Felipe Sodré Ribeiro, Walisson de Araújo Peixoto, Karen Hayanna Gama Gurgel, Lorenna Silveira Decarli, Adriana Silva Pontes Araujo
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