COENZYME Q10 SUPPLEMENTATION IN THE TREATMENT OF HEART FAILURE
DOI:
https://doi.org/10.36557/2674-9432.2026v5n4p266-283Keywords:
Coenzyme Q10, heart failure, supplementation, cardiac function, adjuvant therapy.Abstract
Heart failure is a clinical syndrome with high prevalence, associated with elevated morbidity and mortality rates, representing a major public health problem. In this context, coenzyme Q10 (CoQ10) has been investigated as an adjuvant therapy due to its role in mitochondrial energy production and the reduction of oxidative stress. The study aimed to examine, based on evidence available in the literature, the benefits of coenzyme Q10 supplementation in the treatment of heart failure. This is a narrative review based on randomized clinical trials, meta-analyses, and systematic reviews. The results show that coenzyme Q10 is associated with improvements in relevant clinical parameters, such as ejection fraction, functional capacity, quality of life, and reduction in hospitalizations, as well as a possible impact on mortality. However, the findings are heterogeneous, especially in patients with preserved ejection fraction. It is concluded that coenzyme Q10 presents potential as a complementary therapy in the management of heart failure, although further studies are required to standardize dosage and duration of intervention.
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Copyright (c) 2026 Fellipe Brunno Negreiros Pimenta, Maria Eduarda da Silva Neto, Francisca Marta Nascimento de Oliveira Freitas, Rosimar Honorato Lobo
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