THE INFLUENCE OF STRESS ON THE PATHOPHYSIOLOGY AND MAINTENANCE OF CHRONIC PAIN

UMA REVISÃO INTEGRATIVA DA LITERATURA

Authors

DOI:

https://doi.org/10.36557/2674-9432.2026v5n1p2355-2375

Keywords:

Chronic pain, Stress, Pathophysiology, Physiotherapy, Biopsychosocial Model

Abstract

A dor crônica é um fenômeno multidimensional que transcende a lesão tecidual, sendo influenciada por mecanismos psicofisiológicos complexos. O objetivo deste estudo foi analisar, por meio de uma revisão integrativa, a influência do estresse na fisiopatologia e na manutenção da cronicidade álgica. A busca foi realizada na base de dados PubMed, abrangendo o período de 2022 a 2026, utilizando descritores controlados (MeSH) e filtros para o topo da pirâmide de evidência (Ensaios Clínicos Aleatorizados, Revisões Sistemáticas e Metanálises). Após o processo de triagem baseado nas diretrizes PRISMA, foram selecionados 17 artigos. Os resultados evidenciam que o estresse crônico atua como um mediador crítico na sensibilização central e na neuroinflamação, onde variáveis como o estresse pós-traumático, a raiva e a percepção de injustiça potencializam a interferência da dor na funcionalidade. Observou-se que intervenções voltadas à modulação do estresse, como o exercício aeróbico e o mindfulness, apresentam eficácia na modulação da dor e na melhora do prognóstico clínico. Conclui-se que o manejo do estresse é indispensável para a prática fisioterapêutica fundamentada no modelo biopsicossocial, sendo um fator determinante para interromper o ciclo de persistência da dor e promover a recuperação funcional.

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Author Biographies

Piero Augusto Zorzi da Silva, Universidade Franciscana

Physical Therapist graduated from the Franciscan University (UFN). Specialist in Trauma-Orthopedic and Sports Physical Therapy. Post-graduate student in Osteopathy at the Madrid School of Osteopathy (EOM). Clinical practice in Trauma-Orthopedic Physical Therapy with emphasis on Evidence-Based Practice (EBP).

Jonas Aléxis Skupien, Universidade Franciscana

Master in Biosciences and Rehabilitation. Professor at the Franciscan University (UFN) and tutor of Multiprofessional Residencies in Physical Rehabilitation and Neurology. He has 14 years of experience in higher education, focusing on research, extension, and academic advising.

References

AFARI, N. et al. Psychological trauma and functional somatic syndromes: a systematic review and meta-analysis. Psychosomatic Medicine, [s. l.], v. 76, n. 1, p. 2-11, 2014.

AGUIRRE DE CÁRCER VIDAL, A.; ALCÓN, M. F. R.; SOTORRÍO, E. I. Fibromyalgia and post-traumatic stress disorder: A systematic review. Psychiatry Research, [s. l.], v. 351, 116635, 2025.

ÅKERBLOM, S. et al. Prolonged exposure for pain and comorbid PTSD: a single-case experimental study of a treatment supplement to multiprofessional pain rehabilitation. Scandinavian Journal of Pain, [s. l.], v. 22, n. 2, p. 305-316, 2022.

ALKASSABI, O. et al. Risk Factors to Persistent Pain Following Musculoskeletal Injuries: A Systematic Literature Review. International Journal of Environmental Research and Public Health, [s. l.], v. 19, n. 15, 9318, 2022.

BONEZZI, C. et al. The Need for a Shared Language in Pain Medicine: The Important Role of IASP Terminology. Journal of Pain Research, [s. l.], v. 13, p. 1355-1362, 2020.

BURNS, J. W. et al. Cognitive Therapy, Mindfulness-Based Stress Reduction, and Behavior Therapy for the Treatment of Chronic Pain: Predictors and Moderators of Treatment Response. The Journal of Pain, [s. l.], v. 25, n. 6, 104460, 2024.

BUSHNELL, M. C.; CEKO, M.; LOW, L. A. Cognitive and emotional control of pain and its disruption in chronic pain. Nature Reviews Neuroscience, [s. l.], v. 14, n. 7, p. 502-511, 2013.

COHEN, S. P.; VASO, L.; HOOTEN, W. M. Dor crônica: uma atualização sobre sobrecarga, melhores práticas e novos avanços. The Lancet, [s. l.], v. 397, n. 10289, p. 2082-2097, 2021.

GOLDSMITH, E. S. et al. Barriers and Facilitators of Evidence-Based Psychotherapies for Chronic Pain in Adults: A Systematic Review. The Journal of Pain, [s. l.], v. 24, n. 5, p. 742-769, 2023.

HAUN, J. N. et al. Outcomes of a Remotely Delivered Complementary and Integrative Health Partnered Intervention to Improve Chronic Pain and Posttraumatic Stress Disorder Symptoms: Randomized Controlled Trial. Journal of Medical Internet Research, [s. l.], v. 26, e57322, 2024.

HOTTA, J. et al. The associations of trauma and posttraumatic stress symptoms with pain and its psychological correlates in patients with chronic pain. Scientific Reports, [s. l.], v. 12, n. 1, 15303, 2022.

JAHN, A. et al. Occupational psychosocial exposures and chronic low-back pain: a systematic review and meta-analysis. Scandinavian Journal of Work, Environment & Health, [s. l.], v. 50, n. 5, p. 329-340, 2024.

KARIMOV-ZWIENENBERG, M. et al. Childhood trauma, PTSD/CPTSD and chronic pain: A systematic review. PLoS One, [s. l.], v. 19, n. 8, e0309332, 2024.

LANGLEY, P. C. et al. The prevalence, correlates and treatment of pain in the European Union. Current Medical Research and Opinion, [s. l.], v. 29, n. 5, p. 463-480, 2013.

LEYDE, S. et al. Mental Health Distress Is Associated With Higher Pain Interference in Patients With Opioid Use Disorder Stabilized on Buprenorphine or Methadone. Substance Use & Addiction Journal, [s. l.], v. 45, n. 3, p. 423-433, 2024.

MEINTS, S. M.; EDWARDS, R. R. Evaluating psychosocial contributions to chronic pain, outcomes, and costs. Progress in Neuro-Psychopharmacology and Biological Psychiatry, [s. l.], v. 87, p. 168-182, 2018.

MICKLE, A. D. et al. Peripheral and central mechanisms of pain generation. Journal of Oral & Facial Pain and Headache, [s. l.], v. 29, n. 4, p. 364-375, 2015.

NICHOLAS, M. et al. The IASP classification of chronic pain for ICD-11: chronic primary pain. Pain, [s. l.], v. 160, n. 1, p. 28-37, 2019.

PILET, C. et al. The role of emotions reported in the emergency department in four-month chronic pain development: Effects of sadness and anger. American Journal of Emergency Medicine, [s. l.], v. 92, p. 52-59, 2025.

REED II, D. E. et al. The mediating role of posttraumatic stress disorder symptoms in pain cognitions among Veterans with chronic pain. Military Psychology, [s. l.], v. 37, n. 2, p. 95-104, 2025.

RODRÍGUEZ, M. N. et al. Trauma exposure across the lifespan among individuals engaged in treatment with medication for opioid use disorder: differences by gender, PTSD status, and chronic pain. Substance Abuse Treatment, Prevention, and Policy, [s. l.], v. 19, n. 1, 25, 2024.

ROOSE, E. et al. The Prevalence of Perceived Injustice and Factors Associated With Perceived Injustice in People With Pain: A Systematic Review With Meta-analysis. Pain Physician, [s. l.], v. 26, n. 2, p. E1-E49, 2023.

SAPOLSKY, R. M. Behave: The Biology of Humans at Our Best and Worst. [s. l.]: Penguin Books, 2017. (Nota: Ajustado o ano para a edição original/comum, conforme citado no texto).

SCHOENLE, P. D. et al. The relationship between post-traumatic stress disorder and chronic pain: a systematic review of the L-type calcium channel’s role. Frontiers in Pain Research, [s. l.], v. 2, 705844, 2021.

TANDZI TONLEU, F. et al. Anger at emergency department discharge increases chronic pain risk at four months. American Journal of Emergency Medicine, [s. l.], v. 99, p. 31-38, 2026.

TREEDE, R. D. et al. Chronic pain as a symptom or a disease: the IASP classification of chronic pain for the International Classification of Diseases (ICD-11). Pain, [s. l.], v. 160, n. 1, p. 19-27, 2019.

TREEDE, R. D. et al. Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology, [s. l.], v. 70, n. 18, p. 1630-1635, 2008.

WIPPERT, P. M.; PUERTO VALENCIA, L.; DRIEẞLEIN, D. Stress and Pain. Predictive (Neuro)Pattern Identification for Chronic Back Pain: A Longitudinal Observational Study. Frontiers in Medicine, [s. l.], v. 9, 828954, 2022.

WITTCHEN, P. J. et al. Running improves mental health symptoms and pain catastrophising in adults with chronic low back pain: a secondary analysis of the ASTEROID randomised controlled trial. Journal of Science and Medicine in Sport, [s. l.], v. 29, n. 1, p. 79-84, 2026.

WOOLF, C. J. Central sensitization: Implications for the diagnosis and treatment of pain. Pain, [s. l.], v. 152, n. 3, p. S2-S15, 2011.

ZETTERBERG, H. et al. Preventing Pain and Stress-Related Ill-Health in Employees: A 6-Months Follow-Up of a Psychosocial Program in a Cluster Randomized Controlled Trial. Journal of Occupational Rehabilitation, [s. l.], v. 33, n. 2, p. 316-328, 2023.

Published

2026-03-08

How to Cite

ZORZI DA SILVA, Piero Augusto; SKUPIEN, Jonas Aléxis. THE INFLUENCE OF STRESS ON THE PATHOPHYSIOLOGY AND MAINTENANCE OF CHRONIC PAIN: UMA REVISÃO INTEGRATIVA DA LITERATURA . Periódicos Brasil. Pesquisa Científica, Macapá, Brasil, v. 5, n. 1, p. 2355–2375, 2026. DOI: 10.36557/2674-9432.2026v5n1p2355-2375. Disponível em: https://periodicosbrasil.emnuvens.com.br/revista/article/view/694. Acesso em: 15 may. 2026.