EFFICACY OF TRANEXAMIC ACID IN THE PREVENTION OF POSTPARTUM HEMORRHAGE: A NARRATIVE LITERATURE REVIEW
DOI:
https://doi.org/10.36557/2674-9432.2026v5n3p512-521Keywords:
Postpartum Hemorrhage; Tranexamic Acid; Prevention; Maternal HealthAbstract
Postpartum hemorrhage (PPH) remains one of the leading causes of maternal morbidity and mortality worldwide, requiring effective strategies for prevention, early recognition, and timely management. In this context, tranexamic acid has been investigated as a pharmacological intervention capable of reducing obstetric blood loss through inhibition of fibrinolysis. This study aimed to analyze the efficacy of tranexamic acid in the prevention of postpartum hemorrhage based on contemporary scientific literature. This is a narrative literature review conducted through searches in databases such as PubMed, Scopus, and the Virtual Health Library, using descriptors related to tranexamic acid, postpartum hemorrhage, and prevention. Studies published between 2018 and 2026 were prioritized, including randomized clinical trials, systematic reviews, international recommendations, and clinical guidelines. Findings indicate that tranexamic acid may reduce blood loss during childbirth, particularly in cesarean deliveries, although its effectiveness in reducing major clinical outcomes such as transfusion and maternal mortality remains inconsistent. In vaginal deliveries, recent evidence suggests limited benefit when used prophylactically alongside active management of the third stage of labor. It is concluded that tranexamic acid represents a promising strategy; however, its preventive use should be individualized, integrated into institutional protocols, and supported by careful risk assessment.
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Copyright (c) 2026 Kellen de Pícoli Alexandre, Rodolfo de Oliveira Medeiros, Cristiano Machado Galhardi, Melissa Antunes, Marília Bedani de Oliveira, Felipe Colatto Alves, Ana Clara Moreira Seabra, Hacise Colatto, Laysa Ohana Mada, Felipe Ravazzi Guzzo, Maria Victoria Santos Kloster, Eduardo Antônio Ferro Faria, Izabela Manfio Rorato
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