INFLUENCE OF IRON AVAILABILITY ON ANTIMICROBIAL RESISTANCE OF CORYNEBACTERIUM STRIATUM STRAINS ISOLATED FROM A NOSOCOMIAL OUTBREAK.

Autores/as

  • Fellipe de Oliveira Cabral Institute of Microbiology Paulo de Góes, Health Science Center, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. https://orcid.org/0000-0002-2257-4481
  • Guilherme Goulart Cabral-Oliveira Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Department of Microbiology, Immunology Parasitology, Faculty of Medical Sciences, Rio de Janeiro State University, Av. 28 de Setembro 87 fundos, 3º andar, 20551-030, Rio de Janeiro, RJ, Brazil https://orcid.org/0000-0001-9762-4669
  • Arize Duarte Vieira Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Department of Microbiology, Immunology Parasitology, Faculty of Medical Sciences, Rio de Janeiro State University, Av. 28 de Setembro 87 fundos, 3º andar, 20551-030, Rio de Janeiro, RJ, Brazil https://orcid.org/0009-0008-2075-1019
  • Cynara Luziet Lages do Nascimento Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Department of Microbiology, Immunology Parasitology, Faculty of Medical Sciences, Rio de Janeiro State University, Av. 28 de Setembro 87 fundos, 3º andar, 20551-030, Rio de Janeiro, RJ, Brazil https://orcid.org/0009-0006-3201-4900
  • Cíntia Silva dos Santos Center for the Control of Zoonoses and Vector-Borne Diseases of Niteroi, RJ, Brazil https://orcid.org/0000-0002-0866-0885
  • Cassius de Souza Araruama Union College of Education – UNILAGOS - Parque Hotel, Araruama, RJ, Brazil. https://orcid.org/0000-0002-5009-5250
  • Ana Luíza de Mattos Guaraldi Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Department of Microbiology, Immunology Parasitology, Faculty of Medical Sciences, Rio de Janeiro State University, Av. 28 de Setembro 87 fundos, 3º andar, 20551-030, Rio de Janeiro, RJ, Brazil https://orcid.org/0000-0003-2522-0416

DOI:

https://doi.org/10.36557/2674-9432.2026v5n1p2225-2241

Palabras clave:

Iron, Antimicrobials, Corynebacterium striatum, Multidrug resistance, Nosocomial outbreak

Resumen

Corynebacterium striatum, a Gram-positive rod of the normal human microbiota, has emerged as a virulent, multidrug-resistant (MDR) pathogen, responsible for a growing number of invasive infections and nosocomial outbreaks worldwide. Previously considered a contaminant, its pathogenicity was recognized in the 1980s, with MDR strains frequently isolated in long-term hospitalized patients exposed to broad-spectrum antibiotics and invasive devices. Resistance to multiple antimicrobials has been common, with vancomycin and linezolid being the most effective agents in vitro. Iron is a vital cofactor, and its limited availability in the host is a common defense mechanism in bacterial infections. However, this adverse condition induces the microorganism to modify phenotypically and express virulence factors, with iron regulation being linked to pathogenicity in C. diphtheriae and other genera. Given the limited knowledge about this regulation in C. striatum, this study aimed to evaluate the influence of iron limitation and supplementation on the antimicrobial susceptibility profile of eight clinical strains isolated during and after a hospital outbreak in Rio de Janeiro. Iron limitation and supplementation altered the susceptibility profile of several strains to multiple antimicrobials. Four moxifloxacin-resistant strains became sensitive under iron limitation or supplementation. Conversely, the sensitive strain BR2376/X acquired an MDR profile under both conditions. Only vancomycin and linezolid maintained unchanged efficacy in all strains tested under all conditions. These changes strongly suggest the influence of metal-dependent transcriptional regulators on bacterial metabolism, and the formation of reactive oxygen species induced by changes in metal concentration, indicating that altering iron homeostasis can be considered a strategy to overcome antimicrobial resistance in C. striatum.

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Publicado

2026-03-01

Cómo citar

CABRAL, Fellipe de Oliveira; CABRAL-OLIVEIRA, Guilherme Goulart; VIEIRA, Arize Duarte; NASCIMENTO, Cynara Luziet Lages do; SANTOS, Cíntia Silva dos; SOUZA, Cassius de; GUARALDI, Ana Luíza de Mattos. INFLUENCE OF IRON AVAILABILITY ON ANTIMICROBIAL RESISTANCE OF CORYNEBACTERIUM STRIATUM STRAINS ISOLATED FROM A NOSOCOMIAL OUTBREAK. Periódicos Brasil. Pesquisa Científica, Macapá, Brasil, v. 5, n. 1, p. 2225–2241, 2026. DOI: 10.36557/2674-9432.2026v5n1p2225-2241. Disponível em: https://periodicosbrasil.emnuvens.com.br/revista/article/view/682. Acesso em: 17 ago. 2026.

Número

Vol. 5 Núm. 1 (2026): Periódicos Brasil. Pesquisa Científica - QUALIS A3

Sección

Ciências Biológicas

Licencia

Derechos de autor 2026 Fellipe de Oliveira Cabral, Guilherme Goulart Cabral-Oliveira, Arize Duarte Vieira, Cynara Luziet Lages do Nascimento, Cíntia Silva dos Santos, Cassius de Souza, Ana Luíza de Mattos Guaraldi

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