DOENÇA DE CHAGAS CONGÊNITA: PANORAMAS TERAPÊUTICOS ATUAIS

Authors

  • Ernesto Brandão de Albuquerque Maranhão Graduando em Medicina pelo Centro Universitário de Maceió
  • Lucas Gabriel Lopes Donato Graduando em Medicina pelo Centro Universitário de Maceió
  • Lucas Alves de Azevedo Graduando em Medicina pelo Centro Universitário de Maceió
  • Laura Vilela de Medeiros Graduanda em Medicina pelo Centro Universitário de Maceió
  • Paulo Sérgio de Souza Larrea Graduada em Medicina pelo Universidade Federal da Grande Dourados
  • Rhayran Espindola Rodrigues Graduada em Medicina pelo Universidade Federal da Grande Dourados
  • Julianna Miranda Gomes Graduado em Medicina pelo FAHESP/IESVAP- Instituto de Educação Superior do Vale do Parnaíba
  • Amanda Virgínia Oliveira Leite Graduada em Medicina pela Faculdade de Medicina de Olinda
  • Edney Marcelo de Melo Aragão Júnior Graduando em Medicina pelo Centro de Estudos Superiores de Maceió
  • Martha de Araujo Medeiros Pereira Graduado em Medicina pelo Centro de Estudos Superiores de Maceió
  • Leonardo Mota Silva Graduando em Medicina pelo Centro de Estudos Superiores de Maceió
  • Markos Paulo Alves Ferreira Graduando em Medicina pelo Centro de Estudos Superiores de Maceió
  • Ane Valéria Cardoso Nobre Residente de cirurgia geral do Hospital Calixto Midlej Filho - Santa Casa de Misericórdia de Itabuna,
  • Camila Andrade Brandão Graduanda em Medicina pela Universidade Tiradentes.

DOI:

https://doi.org/10.36557/pbpc.v3i2.118

Keywords:

congenital Chagas disease, pregnancy, and treatment

Abstract

Congenital Chagas disease is an infection caused by the parasite Trypanosoma cruzi, transmitted vertically from mother to child during pregnancy. The pathogenesis is complex and can affect several organs and systems of the newborn. Symptoms can vary widely, from asymptomatic to severe manifestations. Neonatal clinical signs may include hepatomegaly, splenomegaly and, in more severe cases, Chagas cardiomyopathy or neurological disorders. Methods: This is an integrative review conducted through the Scopus, PubMed® and SciELO databases, using the descriptors congenital Chagas disease, pregnancy and treatment. Studies published in the last 14 years, in English, Spanish or Portuguese, that addressed the topic were included. Results and discussions: Early detection of congenital infection in neonates is crucial for the implementation of effective treatment and the prevention of long-term complications. The choice between benznidazole and nifurtimox should be based on the adverse effects profile and individual response to treatment, with benznidazole being the first choice due to its better tolerability in pediatric populations and ease of obtaining. Conclusion: Early identification of the condition, followed by rigorous monitoring and appropriate therapeutic management are crucial to improve clinical outcomes in neonates with congenital Chagas disease.

References

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Published

2024-08-15

Issue

Vol. 3 No. 2 (2024): PBPC 2024

Section

Ciências da Saúde

License

Copyright (c) 2024 Ernesto Brandão de Albuquerque Maranhão, Lucas Gabriel Lopes Donato , Lucas Alves de Azevedo, Paulo Sérgio de Souza Larrea , Rhayran Espindola Rodrigues , Julianna Miranda Gomes , Edney Marcelo de Melo Aragão Júnior , Martha de Araujo Medeiros Pereira , Leonardo Mota Silva , Markos Paulo Alves Ferreira, Amanda Virgínia Oliveira Leite

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