Sclerotherapy with monoethanolamine oleate in the management of multiple oral venolymphatic malformations associated with systemic involvement: case report and literature review.

Authors

DOI:

https://doi.org/10.36557/2674-9432.2026v5n2p470-484

Keywords:

Vascular anomalies, Sclerotherapy, Monoethanolamine oleate, Oral cavity, Case report

Abstract

Oral vascular anomalies represent a therapeutic challenge due to potential surgical morbidity. This study reports the clinical management of a patient with multiple oral vascular malformations treated conservatively with 5% monoethanolamine oleate sclerotherapy. The protocol consisted of serial intralesional injections with controlled volumes and variable intervals (mean of 24 days), based on clinical response. Progressive regression of the lesions and functional improvement were observed, with no severe systemic or local complications. The flexibility in the interval between sessions did not compromise the outcome, suggesting an adaptable therapeutic window. In conclusion, monoethanolamine oleate is a viable option for the minimally invasive management of multiple oral vascular anomalies, especially when surgical approaches are contraindicated.

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References

International Society for the Study of Vascular Anomalies (ISSVA). ISSVA classification for vascular anomalies. 2018 [updated 2018]. Available from: https://www.issva.org/classification

Zeevi I, et al. Sclerotherapy of vascular malformations in the oral cavity: a retrospective cohort study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020;129(5):456–463.

Silva HC, et al. Minimally invasive treatment of benign oral vascular lesions: a narrative review. J Stomatol Oral Maxillofac Surg. 2025;126(1):15–23.

Tolentino ES, et al. Monoethanolamine oleate sclerotherapy for the treatment of intraoral vascular anomalies. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020;130(3):273–279.

Barros CCS, et al. Evaluation of sclerotherapy of benign oral vascular lesions with monoethanolamine oleate. Clin Oral Investig. 2021;25(4):1767–1774.

Kato CN, Ribeiro MC, Abreu MHNG, et al. What is the preferred concentration of ethanolamine oleate for sclerotherapy of oral vascular anomalies? Med Oral Patol Oral Cir Bucal. 2020;25(4):e468–e473.

De Oliveira MS, Pegas MA, De Deus LP, Chandretti PCS, Vilela EM. Photobiomodulation associated with sclerotherapy for treatment of hemangioma in the hard palate. J Vasc Bras. 2021;20:e20200151.

Peres HP, et al. Low-dose ethanolamine oleate sclerotherapy for oral vascular anomalies: clinical outcomes and safety. Oral Surg Oral Med Oral Pathol Oral Radiol. 2025;139(2):214–221.

Ozaki M, et al. Effect and safety of ethanolamine oleate in sclerotherapy in patients with difficult-to-resect venous malformations: a multicenter single-arm study. PLoS One. 2025;20(1):e0301234.

Anwar SK, et al. Bloodless management of oral vascular lesions: diode laser versus sclerotherapy. Lasers Med Sci. 2022;37(6):2599–2606.

Fukuzawa S, et al. Therapeutic effect of polidocanol sclerotherapy on oral vascular malformations. Int J Environ Res Public Health. 2021;18(10):1–10.

De Maria L, De Sanctis P, Balakrishnan K, Tollefson M, Brinjikji W. Sclerotherapy for venous malformations of head and neck: systematic review and meta-analysis. Neurointervention. 2020;15(1):4–17. doi:10.5469/neuroint.2019.00213.

Published

2026-04-07

How to Cite

SOPRANI, GABRIELLY CORREA; MAIA, LEILANE MELO; HAGE, CAIO DE ANDRADE. Sclerotherapy with monoethanolamine oleate in the management of multiple oral venolymphatic malformations associated with systemic involvement: case report and literature review. Periódicos Brasil. Pesquisa Científica, Macapá, Brasil, v. 5, n. 2, p. 470–484, 2026. DOI: 10.36557/2674-9432.2026v5n2p470-484. Disponível em: https://periodicosbrasil.emnuvens.com.br/revista/article/view/820. Acesso em: 27 apr. 2026.